Higuchi and connors

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August undefined, 2024

WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Ibuprofen-Maltodextrin Interaction: Study of Enantiomeric Recognition and Complex Characterization WebIt is a blood scihozonticide and active against all stages of Plasmodium falciparum. The drug is also used for the treatment of cerebral malaria as well as for the chloro- quine resistant cases [2-5]. Unfortunately, it is water- insoluble (17 µg/ml at room temperature) [6] and the formulation causes difficulties to the biopharmaceutical scientist.

Higuchi T, Connoras KA. Phase-solubility techniques, ADV Anal Chem …

WebThe Higuchi窶鼎onnors phase-solubility method8)is very often used to determine K 1:1 , as a part of a formulation study. This method is based on the effect of a complex forming lig- and, e.g.CD, on the solubility of the drug. The intrinsic solu- bility (S 0 ) and the slope of the phase-solubility diagram are then used to calculate K 1:1 WebHiguchi and Gensch, "Acylation through a Sulfonium Ion Intermediate. Coupled Conversion of a Carboxylic Acid to an Acid Anhydride during Oxidation of a Thioether to a Sulfoxide,", … canadian detective series tv

Analysis of the phase solubility diagram of a …

WebMar 28, 2014 · Solubility studies were performed according to the method reported by Higuchi and Connors and the phase solubility diagrams were plotted. The repaglinide-nanosponges complexes were prepared, lyophilized and the resulted inclusion complexes were characterized by FT-IR and NMR. WebThe most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that … WebIn vitro transdermal permeation behavior of isosorbide dinitrate in the absence and presence of 2-hydroxypropyl-β-cyclodextrin: solutions and suspensions. Interactions of a vasodilator, isosorbide dinitrate (ISDN), with the parent α-, β- and γ-cyclodextrins (α-, β- and γ-CDs) and 2-hydroxypropyl-α- and -β- and γ-CDs (HP-α- and -β ... fisher hd2 plow price

Binary and Ternary Complexes of Arteether β-CD

Solubility enhancement and application of cyclodextrins in

WebThis was explained by the solubilization theory of Higuchi and Connors. The solubility analysis of the ternary drug/competitor/CyD systems may be particularly useful for … WebSolubility profiles by Higuchi and Connors theory. So is the drug intrinsic solubility in cyclodextrin absence 76 . Source publication Alternative Technologies to Improve … fisher hd2 plow for saleWebHiguchi et. al, "Phase-Solubility Technique in Studying the Formation of Complex Salts of Triamterene,", 1964. Higuchi and Connors, "Phase-Solubility Techniques,", 1964. Higuchi … canadian diabetes association sudbury

"WebMar 30, 2024 · The phase solubility study was carried out according to the method of Higuchi and Connors ( Higuchi, & Connors, 1965 ). Specifically, excessive APG (approximately 10 mg) was added to 5 mL of ethanol–water (30:70, v/v) solution containing different concentrations of OMT in the range of 5–300 mM. " - Higuchi and connors

Higuchi and connors

WebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ( [H 4 MGF] = f ( [βCD])) of saturated solutions in mangiferin must show a linear trend and then equation ( 6) relates the slope ( α) and intercept ( G0) of the straight line with the equilibrium … WebThe present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ...

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http://www.sciepub.com/reference/10360 WebT. Higuchi, A. Connors Published 1965 Chemistry No Paper Link Available Save to Library Create Alert Cite 2,633 Citations Citation Type More Filters Development of Solvent-Free …

WebMay 9, 2007 · A phase solubility study was performed, according to the method reported by Higuchi and Connors, to evaluate the changes of isoflavone in the complexation state and the obtained diagrams suggested that it forms complexes with a stoichiometry of 1:1. WebT. Higuchi and K. A. Connors, “Phase-Solubility Techniques,” In: C. N. Reilly, Ed., Advances in Analytical Chemistry and Instrumentation, Wiley-Interscience, New York, Vol. 4, 1965, pp. …

WebJan 1, 2011 · T. Higuchi, K.A. Connors. Phase solubility techniques. Adv Anal Chem Instrum, 4 (1965), pp. 117-212. Google Scholar [18] L. Greenspan. Humidity Fixed Points of Binary Saturated Aqueous Solutions. J Res Nat Bur Stand, 81A (1) (1977), pp. 89-96. CrossRef Google Scholar [19] WebMay 11, 2024 · Cyclodextrins (CDs), a group of oligosaccharides formed by glucose units bound together in a ring, show a promising ability to form complexes with drug molecules …

WebPersonal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library. Higuchi and Connors, "Spectrophotometric Detection of the End Point in the Karl Fischer Titration of Water,", 1959, Box: 11, Folder: 110. Personal papers of Takeru Higuchi, PP 359. University of Kansas. Kenneth Spencer Research Library.

WebApr 7, 2024 · The most dramatic increase in solubility of curcumin was obtained more than 20 times higher by solidly dispersed complex of CUR with PEG 6000 (1:3) than its intrinsic solubility. Following the classification of Higuchi and Connors, CUR in different PEG 6000 solutions showed A N diagram. canadian diabetes association manitobaWebAug 8, 2024 · The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = … fisher hd2 snow foilWebMay 1, 1999 · There are many methods for determination of stability constants of CyD complexes, using techniques such as solubility ( Higuchi and Connors, 1965 ), potentiometry ( Miyaji et al., 1976 ), high-pressure liquid chromatography ( Uekama et al., 1978 ), and kinetic ( Bender and Komiyama, 1978) and spectroscopic ( Cramer et al., 1967, Thakkar et … canadian diabetes association new brunswickWebPhase solubility diagrams and their classification according to Higuchi and Connors. S0 is the intrinsic solubility of drugs in aqueous medium. Source publication +4 Cyclodextrins in Drug... canadian development finance initiativeWebMar 22, 2024 · We also introduced the Higuchi and Connors method to analyze inclusion complex formed through solubilization and the pharmaceutical benefits that can be gained using CDs. In addition, the practical applications of CDs in nasal, ophthalmic, pulmonary, and rectal drug delivery are also described. CD applications for drug solubilization canadian diabetes educator boardWebT. Higuchi and K. A. Connors, “Phase-Solubility Tech-niques,” Advances in Analytical Chemistry and Instru-mentation, Vol. 53, No. 4, 1965, pp. 117-212. - References - Scientific … canadian diagnostic imaging sherwood park canadian diabetes association logo