Myotubularin-related protein 13

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WebMyotubularin-related proteins constitute one of the largest and most highly conserved protein tyrosine phosphatase (PTP) subfamilies in eukaryotes [14, 19]. The MTM family … WebMar 19, 2014 · MYOTUBULARIN-RELATED 13; MTMR13 KIAA1766 HGNC Approved Gene Symbol: SBF2 Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,778,668-10,294,219(from NCBI) Gene-Phenotype Relationships Location

Myotubularin - Wikipedia

WebApr 10, 2024 · The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH-GRAM domain, and can hydrolyze phosphatidylinositol (3)-phosphate and phosphatidylinositol (3,5)-biphosphate in vitro. Web1 day ago · Protein won't give you the quick energy boost that sugars do, even though protein and carbohydrates have the same energy value (meaning gram for gram they have the same amount of calories). fortnite minty axe pfp

MTMR2 myotubularin related protein 2 - NIH Genetic Testing …

WebPromotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates … WebMTMR2 myotubularin related protein 2 Gene ID: 8898, updated on 29-Mar-2024 Gene type: protein coding Also known as: CMT4B; CMT4B1. See all available tests in GTR for this … WebJun 13, 2015 · Myotubularin-related protein 1 (MTMR1) is a phosphatase that belongs to the tyrosine/dual-specificity phosphatase superfamily. MTMR1 has been shown to use phosphatidylinositol 3-monophosphate (PI(3)P) and/or phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) as substrates. Here, we determined the crystal structure of … dining table not aligned with light

MTMR14 myotubularin related protein 14 [ Homo sapiens (human) ]

8897 - Gene ResultMTMR3 myotubularin related protein 3 [ (human)]

WebJul 19, 2003 · Myotubularin-related protein 1 Curated Alternative names Phosphatidylinositol-3,5-bisphosphate 3-phosphatase. EC:3.1.3.95 ( UniProtKB ENZYME Rhea) 1 publication Phosphatidylinositol-3-phosphate phosphatase. EC:3.1.3.64 ( UniProtKB ENZYME Rhea) 1 publication Gene names Name MTMR1 Imported Organism names … WebOct 20, 2012 · Studies in cultured cells showed that several myotubularins are associated to endosomal compartments and other intramembranes i.e. profiles consistent with involvements of these proteins in the control of PtdIns3 P and PtdIns (3,5) P 2 signaling to regulate protein trafficking at the endosomal system. dining table nzWebApr 5, 2012 · In mammals, the myotubularin family is composed of MTM1 and 13 MTM1-related (MTMR) proteins named MTMR1 to MTMR13 [11], [12] ( Figure 2 ). All contain PTP-like and PH-GRAM domains. Six MTM family members contain an inactive catalytic site owing to conserved substitutions of several amino acids essential for activity [11], [13], [14]. dining table next to sofa

"WebThe myotubularin gene, MTM1, is mutated in the genetic disorder, X-linked myotubular myopathy. We and others have previously shown that myotubularin utilizes the lipid second messenger, phosphatidylinositol 3-phos-phate (PI(3)P), as a physiologic substrate. We demon-strate here that the myotubularin-related protein " - Myotubularin-related protein 13

Myotubularin-related protein 13

Rab35-regulated lipid turnover by myotubularins represses …

WebMyotubularin 1. Myotubularin is a protein that in humans is encoded by the MTM1 gene. [5] This gene is a member of a gene family that encodes lipid phosphatases. Myotubularin is … WebThese results reveal an essential role for myotubularin-related protein 10 in the protection of dendrite morphology and function against the deleterious effects of oxidative stress or …

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Webmyotubularin-related protein 13 isoform X1 Imported. Gene names. Name. LOC113212775 Imported. Organism names. Organism. ... PTHR10807 MYOTUBULARIN-RELATED 2 hits; … WebJan 15, 2011 · MTMs are known to play a fundamental role in human physiology as gene mutations can give rise to X-linked myotubular myopathy or Charcot-Marie-Tooth disease, which manifest in skeletal muscle or in peripheral neurons respectively.

WebNov 15, 2011 · Myotubularin (MTM1; 300415) and myotubularin-related proteins are dual-specificity phosphatases. Several myotubularin-related proteins (e.g., MTMR1, 300171) have been identified in humans and mice. Members of the myotubularin protein family are highly conserved, from humans to yeast. Mutations in the MTM1 gene lead to X-linked …

WebMar 25, 2008 · The Mtmr13 protein is depicted with indicated protein domains. Cell line RRF511 contains a 3,564-bp deletion that spans exon 17 and the preceding intronic … WebA large family of myotubularin phosphatases dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, which are known to play important roles in vesicular trafficking and autophagy. The family is composed of 16 members, and understanding their regulatory mechanisms is important to understand their functions …

WebJan 8, 2024 · This gene encodes a myotubularin-related protein. The encoded protein is a phosphoinositide phosphatase that specifically dephosphorylates phosphatidylinositol 3,5-biphosphate and phosphatidylinositol 3-phosphate. Mutations in this gene are correlated with autosomal dominant centronuclear myopathy.

WebProtein target information for Myotubularin-related protein 13 (human). Find diseases associated with this biological target and compounds tested against it in bioassay … fortnite minty legend packWebJun 10, 2024 · In this context, we identified 76 kDa myotubularin-related protein 7 (MTMR7), a member of the myotubularin (MTM) family of lipid phosphatases, as a novel interaction … fortnite minty axe targetWebThis gene encodes a member of the myotubularin dual specificity protein phosphatase gene family. The encoded protein is structurally similar to myotubularin but in addition … fortnite minty legends pack best buyWebJul 18, 2000 · Myotubularin contains the Cys-X5-Arg (CX5R) active site motif that is the hallmark of the protein tyrosine phosphatase (PTP) superfamily and exhibits dual specificity protein phosphatase activity in vitro(6–9). In addition, myotubularin-related proteins are conserved among eukaryotes, suggesting a common substrate or function (5, 9). fortnite: minty legends pack ps5WebApr 10, 2024 · The protein can self-associate and also form heteromers with another myotubularin related protein. The protein binds to phosphoinositide lipids through the PH … dining table oak furniture landWebJul 18, 2000 · Myotubularin contains the Cys-X5-Arg (CX5R) active site motif that is the hallmark of the protein tyrosine phosphatase (PTP) superfamily and exhibits dual … dining table offer upMyotubularin domain represents a region within eukaryotic myotubularin-related proteins that is sometimes found with the GRAM domain InterPro: IPR004182. Myotubularin is a dual-specific lipid phosphatase that dephosphorylates phosphatidylinositol 3-phosphate and phosphatidylinositol (3,5)-bi-phosphate. Mutations in gene encoding myotubularin-related proteins have been associat… dining table offers