Phospholipase a2 receptor antibody pla2r
Webbeck等 首次在成人imn患者血清中检测到抗m型磷脂酶a2受体(pla2r)的自身抗体，并发现抗体滴度与患者蛋白尿的消长相关，提示pla2r可能是imn的重要靶抗原。我们前期已针对血清pla2r抗体进行检测，发现病情缓解的imn患者血清学阳性率明显降低，提示单纯采用血 … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Phospholipase a2 receptor antibody pla2r
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WebMay 29, 2024 · The aims of this study were to detect the expression of M phospholipase A2 receptor (PLA2R) in the kidney tissue of patients with idiopathic membranous nephropathy (IMN), secondary membranous nephropathy (SMN), and the nonmembranous nephropathy (non-MN), to evaluate the value of PLA2R in the kidney tissue and serum anti-PLA2R … WebAntibodies to the phospholipase A2 receptor (PLA2R) occur in 70% to 80% of patients. Less frequently (in up to 10%), antibodies against thrombospondin type-1 domain-containing …
WebMar 20, 2024 · Background Most primary membranous nephropathy (MN) is mediated by anti-phospholipase A2 receptor (PLA2R) antibodies. Recently, these antibodies have … WebThe Phosphlipase A2 receptor (PLA2R) was recently discovered as a target autoantigen in patients with idiopathic membranous nephropathy (IMN). Autoantibodies directed to …
WebMar 11, 2024 · Phospholipase A2 receptor (PLA2R)–associated membranous nephropathy (MN) with circulating serum autoantibodies to PLA2R (SAb+) but no deposits of PLA2R antigen in glomerular tissue by immunofluorescence (GAg−) has been reported. However, little is known about the clinicopathological characteristics or prognosis of this subtype of … WebPhospholipase A2 receptor (PLA2R) is present in normal podocytes and in immune deposits in patients with idiopathic membranous nephropathy, indicating that it is a major antigen …
WebSep 18, 2024 · Serum anti-phospholipase A2 receptor (PLA2R) antibody detected at diagnosis as a predictor for clinical remission in patients with primary membranous nephropathy: a meta-analysis Yufeng Liang, Jianxin Wan, Yongping Chen & Yangbin Pan BMC Nephrology 20, Article number: 360 ( 2024 ) Cite this article 7470 Accesses 11 …
WebJul 15, 2024 · (a) PM2.5 induces extrarenal anti-PLA2R antibody production. Inhalation of PM2.5 results in the accumulation and activation of alveoli macrophages and neutrophils. PLA2R that is presented on these cells can be discharged into the inflammatory space, when neutrophil extracellular traps (NETs) and macrophage extracellular traps (METs) are … dutch learning podcastWebBackground: The pathogenesis of primary membranous nephropathy (MN) involves the antibodies against antigens on the cell surface of podocytes, with the majority of M-type phospholipase A2 receptor (PLA2R), and a profound podocyte dysfunction. The effects of anti-PLA2R antibodies directly to the podocytes remain unclear. dutch led projectsWebHave a medical condition that can cause damage to the kidneys including cancer and lupus. Symptoms and Causes What causes membranous nephropathy (MN)? Most cases of MN are now known to be caused by an antibody to a protein on the podocyte called the phospholipase A2 receptor (PLA2R). dutch league winners historyWebFeb 20, 2024 · M-type phospholipase A2 receptor 1 (PLA2R) has been described as a major antigen in iMN, with anti-PLA2R antibodies (Abs) present in ∼70% of incident patients [ 2, 3 ]. The specificity of anti-PLA2R Abs for the diagnosis of iMN, albeit not absolute, is now well established [ 3–5 ]. cryptozoological map of the united statesWebApr 11, 2024 · Approximately 80% of PMN cases arise due to autoantibodies that recognize the phospholipase A2 receptor (PLA2R) antigen expressed on podocytes. Anti-PLA2R is both a diagnostic and prognostic biomarker, and total aPLA2R antibody level has been shown to be a biomarker for prognosis of outcome in patients with PMN. dutch leather company × masayoshi watch beltWebMar 14, 2024 · The discovery of antibodies against M-type phospholipase A2 receptor (PLA2R) situated on the cell surface of human podocytes has been a turning point for the … cryptozoologist b4bWebMar 21, 2024 · PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging. Phospholipase A2 receptor 1 promotes lung cell senescence and … cryptozoologicon bigfoot